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Customer References and Case Studies
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Ernest Gallo Clinic & Research Center
The ventral part of the striatum, nucleus accumbens (NAc), is involved in decision making. Previous studies demonstrated how NAc neurons can drive reward-related behavior in animals. We investigated if these neurons could also encode information necessary to stop a goal-directed behavior. For this purpose we designed a maze where rats had to run over an electrified shock grid to obtain a reward. Two auditory cues informed the rats whether the shock was on. On these trials, the intensity of the shock was titrated so that each rat decided to cross the grid on about 50% of the time. This allows us to compare the neuronal spiking of NAc neurons on go and no go trials. We will present single unit activity recorded in this task with a TBSI 15 channel wireless system that allowed rats to navigate freely in the maze without the movement restriction of a cable attached to a head stage.
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Zhejiang University
To study decoding information in the neural system, invasive brain-machine interfaces (BMIs) in rat were investigated. In this paper we developed a remote control training system for rat navigation. The system consists of an integrated PC control program with functions of signal communication, parameter setting and data file management, a transmitter and a receiver based on Bluetooth modules, and a stimulator controlled by a microprocessor. Stimuli delivered into the rat brain through a wireless micro-stimulator brought the rat to bear virtual cues or rewards and follow the commands to move right, left and forward in 3D obstacle environments. Using wireless neural recording system, the activities of neural ensemble could be recorded in free-moving small animals when they were performing “press-lever” tasks. When rat pressing the level with its forelimb, the value of pressure senor on lever and neural ensemble activities were synchronously recorded.
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Duke University
Data collected from implanted micro wire arrays in conjunction with a 15 channel TBSI wireless headstage in rats in presented. The rats are trained by food reward to classify the duration of a visual stimulus as short (4 s) or long (16 s) by pressing a corresponding lever. Data discussed will include both firing properties of single units and local field potentials recorded wirelessly from the dorsal striatum while the rats were actively estimating the signal durations.
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Brown University
Research is presented on spatial navigation tasks for a rat in a terrain maze environment. Spike recording and video tracking data information will also be acquired during the experiments for feeding tasks.
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Bionic Ear Institute, La Trobe University, Bundoora, Australia
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"A/Prof Tony Paolini heads the Auditory Clinical Neuroscience Unit located at The Bionic Ear Institute and is Reader and Associate Professor within the School of Psychological Science at La Trobe University. The Auditory Clinical Neuroscience Unit is currently undertaking experiments in collaboration with La Trobe University to improve the development of neural prosthetic devices. Using sophisticated multichannel recording methods, combined with micro stimulation, new strategies and approaches to implant development are currently being examined.
"A/Prof Paolini is also Director of Bioengenesis Technologies Pty Ltd, an Australian company that specializes in providing integrated systems for neuroscience, bioengineering, behavioral science and related areas of research and teaching".
"Much of the experimental protocols involved in the development of these devices involves multichannel recording in rats. Acute experiments are conducted using our 256 channel TDT Z series combined with micro stimulation via TDT RX7 devices. We have now embarked on a series of chronic experiments to ascertain brain function and its correlation with behavior. The TBSI 32 channel wireless recording system has allowed this to occur with relative ease. The light weight design and easy of use makes the TBSI wireless system the equipment of choice to allow us to achieve our aim. Behavior can occur unhindered; the degree of freedom is outstanding".
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“The recording quality is of a high standard and noise problems are minimal compared to a conventional tethered system” M. Shivdasani.
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"We chose the 32 channel wireless system because we wanted a wireless solution that would allow clean uninterrupted neural responses to be obtained – free from artifacts induced by movement of wires.
The TBSI team is great. They provide expert advice and resolve problems with relatively easy.
We were so impressed with the TBSI device that we purchased two of them. We highly recommend it. As indicated, we are very impressed with the ease of operation and the quality of the results obtained".
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Do you have any questions? You may email Tony Paolini Tony is willing and has approved to give his email out to customers that would like to have some questions for a reference.
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