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TBSI's Wireless Technology
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NEW...Published Journal Article - The ability to record well-isolated action potentials from individual neurons in naturally behaving animals is crucial for understanding neural mechanisms underlying natural behaviors. Traditional neurophysiology techniques, however, require the animal to be restrained which often restricts natural behavior. An example is the common marmoset (Callithrix jacchus), a highly vocal New World primate species, used in our laboratory to study the neural correlates of vocal production and sensory feedback. When restrained by traditional neurophysiological techniques marmoset vocal behavior is severely inhibited. Tethered recording systems, while proven effective in rodents pose limitations in arboreal animals such as the marmoset that typically roam in a three-dimensional environment. To overcome these obstacles, we have developed a wireless neural recording technique that is capable of collecting single-unit data from chronically implanted multi-electrodes in freely moving marmosets. A lightweight, low power and low noise wireless transmitter (headstage) is attached to a multi-electrode array placed in the premotor cortex of the marmoset. The wireless headstage is capable of transmitting 15 channels of neural data with signal-to-noise ratio (SNR) comparable to a tethered system. To minimize radio-frequency (RF) and electro-magnetic interference (EMI), the experiments were conducted within a custom designed RF/EMI and acoustically shielded chamber. The individual electrodes of the multi-electrode array were periodically advanced to densely sample the cortical layers. We recorded single-unit data over a period of several months from the frontal cortex of two marmosets. These recordings demonstrate the feasibility of using our wireless recording method to study single neuron activity in freely roaming primates.
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Reference
Sabyasachi Roy, Xiaoqin Wang, Wireless Multi-Channel Single Unit Recording in Freely Moving and Vocalizing Primates, Journal of Neuroscience Methods, 2011 Sep 12.
Abstract
Continuous recording of single-unit neuronal activity is an important tool for studying normal and pathological brain function. Current systems typically tether implanted electronics both to remote data processors and power supplies. The tether constrains the animals’ behavior and limits possible experimental designs. Ideally, neural activity could be recorded from behaving animals in a natural and enriched environment. In this paper we present the circuits, layouts and test data for a multi-channel wireless headstage system which includes the headstage transmitter and receiver components. The system was successfully tested in a rat and a macaque monkey implanted with cortical multielectrode arrays.
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NEW A "Peer Reviewed" Research Paper (PLoSOne) using Triangle BioSystem's wireless technology.(Published July 2011) |
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Read more about Triangle BioSystem's wireless technology. (Research Paper) |
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A Wireless Neural Data Acquisition System for increased power efficiency, compact size, robust signaling and reliable transmission is shown and described. In one embodiment, the system includes a headstage, an RF receiver, an analog-to-digital converter, a digital signal processor, and a communication interface. The headstage includes at least one input pre-amplifier high-pass filter and amplifier, a multiplexer (MUX), an RF Modulator compromising a voltage control oscillator (VCO), a transmitting antenna, and a power supply. The RF receiver includes at least one receiving antenna, at least one bandpass filter, at least one amplifier, at least one attenuator, and an FM Demodulator.
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Presentation: Advancements in Wireless Neural Recording Technology
An abstract from a previous Society for Neuroscience (SFN) meeting.
Triangle BioSystems implementation of wireless technologies for small animal neurological testing make it possible for new studies to be obtained without the weight and constraints of wires for the animal. No longer do experiments need to be done by wiring a test subject to the recording system. This recording technology has now become an affordable alternative to tethered solutions and provides accurate and reliable data using the same software that you are using today to collect and analyze your data.
Here we compare and contrast data collected from two technologies, a 15 channel TBSI wireless headstage and a Plexon tethered headstage, discussing similarities and differences in rat behavior, environmental protocols, and analyzed data from single units and local field potentials.
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